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The PNS encompasses all nerves outside of the CNS, and is responsible for all involuntary functions in the body

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Although this enzyme can also inactivate (11-dehydrogenase activity) cortisol and corticosterone by catalyzing the oxidation reactions converting cortisol to cortisone and corticosterone to 11-dehydrocorticosterone, these inactivating reactions are of minimal significance to intracellular glucocorticoid regulation