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The bound toxin becomes water-soluble and is excreted through bile or urine

Therefore, it was concluded that the used treatments were not cytotoxic at the conditions (concentrations and incubation times) used in the study

In support of active mitochondrial biogenesis and elevated respiratory complex-dependent ROS formation during DC differentiation 47,48 , we observed elevated expression of PGC1, TOMM20 and antioxidant GSS persisting through maturation

The details of these factors are described in other reviews [534,535,536]

337 Although all cell types responded to this inhibitor in vitro and showed promising therapeutic effects in vivo, 337 phase I clinical trials for treating advanced solid tumors ultimately failed due to cardiovascular toxicity and wide variability in patient responses

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