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Thus, one can speculate that RBC uptake and consumption of methyl-group donors (e.g., methionine, choline) could compete with other tissues where these substrates are used to fuel epigenetic regulatory mechanisms, such as methylation of proteins (e.g., histones), RNA (N6-methyladenosine) and DNA (CpG islands), making RBCs an indirect player in systemic long-term responses to oxidant stress events

PKLR (encoding L, liver, and R, RBC isoenzymes) is located on chromosome 1q21

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The images were captured using a Canon PowerShot A640 digital camera

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