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Although pharmacological and interventional methods for stroke have been well developed, their functional recovery outcomes remain suboptimal

Small molecule drug discovery approaches mainly focus on protein-ligand interactions that have a much smaller contact area in comparison to the larger featureless interface areas commonly found with PPIs, which also lack the traditional endogenous small molecular ligands used for reference in small-molecule drug discovery

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Additionally, several biomarkers, most importantly CD163, may serve as potential biomarkers and therapeutic targets for acute ischemic stroke, aiding in stroke diagnosis and prognosis

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