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Another enzyme called poly(ADP-ribose) polymerase 1 (PARP-1), a mediator of programmed necrosis activated by oxidative stress, is an important activator of caspase-independent cell death (Zhang et al

doi: 10.1515/cclm-2016-0783

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[2] Additional subunits The quaternary structure of the pyruvate dehydrogenase complex is further complicated, as mentioned previously, by the presence of three additional subunits: a pyruvate dehydrogenase kinase, a pyruvate dehydrogenase phosphatase, and the E 3 -binding protein (E3BP)

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