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Consistent with the notion that this axis directly promotes histone acetylation, supplementation with acetylcarnitine, but not l-carnitine, rescued histone acetylation in cells with knockdown of CrAT (Extended Data Fig

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additionally, alcar raised the transcription of grm2 gene encoding for the mglu2 receptor via increasing the levels of acetylated h3k27 bound to the grm2 promoter and gaining the acetylation of nf-kb-p65 subunit