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The nucleotides profile of R cells is remarkably stable compared to S cells (Additional file 4), only 6 metabolites changing (against 16 in S cells), either in the same direction but lower magnitude then for S cells (ADP, hypoxanthine (HX), UDP and uridine) or in opposite direction i.e
2.2 Pathogenesis and pathophysiology of hyperuricemia Hyperuricemia is the precursor state to gout, but its pathophysiological impact extends far beyond the joints, involving multiple systems, including cardiovascular diseases, chronic kidney disease, and metabolic disorders (Wang Q
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Patients with SCA suffer most severely, and these diseases represent a significant global public health concern, in endemic malaria environments
(1994) Molecular evolution of the eye lens, Prog
