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Safety also depends on the type of supplement and individual health conditions

Liu Y, Yan Z, Zhang L, Deng Z, Yuan J, Zhang S, Chen and Guo R 2019 Food up-take and reproduction performance of Daphnia magna under the exposure of Bisphenols
B12 is water-soluble, so your body uses what it needs and passes much of the extra through your urine

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In 1998, the recommended dietary allowance for all women of child bearing age who are capable of becoming pregnant was increased to 400 mcg of folic acid daily

10.1371/journal.pone.0056525 PLoS One 48 KarlssonL.SchmittU.JosefssonM.CarlssonB.AhlnerJ.BengtssonF.et al (2010)
