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Risk-benefit considerations: Steroids extremely effective but carry significant risks justifying use only when necessary

doi: 10.1111/j.1464-5491.2006.01879.x

Viral respiratory illness increases in the winter and induces robust depletion of the gut microbiome (Yildiz et al., 2018)

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The global economic burden is substantial, with annual costs estimated at $20 - 30 billion, including $10 billion in direct healthcare costs and $15 - 20 billion in productivity losses due to disability (5)