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[PubMed 19160726] 2255

A new role for long chain fatty acid acylation of proteins

Abbreviations AD: Adefovir Dipivoxil ASGPR: Asialoglycoprotein receptor HBc: Core protein cccDNA: Covalently closed circular DNA DOCK11: Dedicator of cytokinesis 11 DAAs: Direct-acting antivirals EPR: Enhanced permeability and retention AuNPs: Gold-NPs GQDs: Graphene quantum dots HAV: Hepatitis A Virus HBV: Hepatitis B Virus HbsAg: Hepatitis B Virus surface antigen HCV: Hepatitis C Virus HDV: Hepatitis D Virus HEV: Hepatitis E Virus LNPs: Lipid-based nanoparticles MNPs: Magnetic nanoparticles Ng: NanoGel NPs: Nanoparticles NLCs: Nanostructured lipid carriers PRRs: Pattern recognition receptors PEG: Polyethylene glycol QDs: Quantum dots RNAi: RNA interference AgNPs: Silver nanoparticles siRNA: Small interfering RNA NTCP: Sodium taurocholate Co-transporting polypeptide receptor SLNs: Solid lipid nanoparticles VLPs: Virus-like particles WHO: World Health Organization References Purcell RH

The following representative PDCs that utilize ester, amide, or carbamate bond linkages to deliver the drug to the target cancer site highlight the potential of these linker chemistries

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BPC-157 ideally goes near the injury for maximum localized effect