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An overabundance of ROS disrupts intracellular redox balance, triggering oxidative stress and elevating susceptibility to ferroptosis

Meng, J., Lv, Z., Wang, Y

We found that the GCL inhibitor BSO re-sensitized IRE1-null cells to erastin-induced ferroptosis, indicating that GCL is involved in IRE1-regulated GSH synthesis (Supplementary Fig

Glutathione (GSH) is a tripeptide compound consisting of glutamate, cysteine, and glycine

Gradual dissolution of NCs within tumor tissue releases Fe 2+ /Fe 3+ and Cu 2+ , which react with AS to generate carbon-centered radicals (C), amplify oxidative stress, deplete GSH, and down-regulate GPX4 and FDX1, thereby triggering ferroptosis and cuproptosis

Acta Pharmacol Sin (2021) 42(1):16070