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Once activated, caspase-8 can induce apoptosis by directly activating caspase-3, or cleaved caspase-8 can lead to apoptosis via the activation of the BH3 interacting-domain death agonist (Bid) (Kantari and Walczak, 2011)

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Cutaneous polyarteritis nodosa involves inflammation of small and medium-sized blood vessels, likely related to deposition of antigen-antibody complexes including hepatitis Be antigen (HBeAg) within vessel walls
