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Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress

If appropriate, anti-hepatitis B therapy may be warranted [see Warnings and Precautions (5.1)]

Effective Dose: 2000 mg/day is associated with significant reductions in body weight, BMI, and fat mass

Key storage recommendations include: Keep refrigerated until ready to use Store unopened pens in the original carton in the refrigerator Never freeze Discard any tirzepatide that has been frozen Protect from light Keep the pen in its original carton Monitor temperature Avoid exposure to temperatures above 86F (30C) Track room temperature storage If storing unrefrigerated, use within 21 days Inspect before use Check for discoloration, particles, or cloudiness Patients traveling with tirzepatide should use insulated medication travel cases with ice packs (ensuring the medication does not come into direct contact with ice)

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