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As early as the 1950s, there were studies suggesting t...

In addition, -LA supplementation dramatically increased reactive oxygen species (ROS) levels and HIF-1 expression, which started the downstream molecular cascade and activated JNK/caspase-3 signaling pathway

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In this review, we summarize the recent advances in the regulation and function of Nrf2 signaling in ferroptosis-activated cancer therapy and explore the prospect of combining Nrf2 inhibitors and ferroptosis inducers as a promising cancer treatment strategy.