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Chemical Society Reviews

36,38,39 Compared to oral administration, whereby under 10% actually enters the blood stream, 52 orobuccal administration leads to over 80% absorption directly into the systemic circulation

Many findings derive from observational or cross-sectional designs that cannot establish causality and are susceptible to confounding by socioeconomic status, overall health, metabolic factors, weight change, and other lifestyle behaviors

10.3390/cells8121502 205 LiQ.SpencerN

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