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Subsequent smooth muscle migration and fibrous fatty plaque formation leads to vessel narrowing or occlusion from plaque growth or rupture and the clinical sequelae of ASCVD including stroke and myocardial infarction

[PubMed: 23871915] 545

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Immune recognition of RNA therapeutics Synthetic mRNA is sensed by innate immune cells through three major categories: (1) uridine-based RNA identification [402], (2) dsRNA recognition [403], and (3) sensing of mRNAs uncapped 5 terminus [404]