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For example, it increases collagen and elastin synthesis, stimulates nerve and blood vessel outgrowth, and can enlarge human hair follicle size

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Indeed, pathogens generally tend to prefer and release mediators to skew macrophage polarization towards an anti-inflammatory phenotype, which is permissive to infection [82], while the host will attempt to enhance the bactericidal properties of macrophages by favouring M1 polarization (Figure 2)

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