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Only those metal sites that rapidly equilibrate with this pool will be sensitive to small perturbations in bioavailable metal concentration that result from cellular metal toxicity or metal restriction

[DOI] [PMC free article] [PubMed] [Google Scholar] Strausak D

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We discuss these proteins in detail, emphasizing general concepts that have emerged from comprehensive studies of these model allosteric switches 18 and more recent efforts to employ metallosensors in synthetic biology and biotechnology applications

Administrator in reply to Cherylclaire my understanding of 'over-use' as in FlipperTD 's response is more to do with patients not being given the opportunity to determine what treatment is most appropriate for them rather than anything to do with saying that you can overdose or become addictive

Finally, we arrive in Cusco, concluding a journey filled with history, landscapes, and living culture