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The American Journal of Clinical Nutrition reported that long-term glutathione supplementation could decrease zinc levels, stressing the importance of monitoring zinc levels during continuous usage

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The antioxidant deficit has been associated with frequent and severe infections that result in increased mortality

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In the course of COPD disease, pro-inflammatory cytokines, ROS, CRP may disrupt the regulation of TJs in brain endothelial cells, increasing BBB permeability, damaging brain cells, and promoting atherosclerosis in both the anterior and internal cerebral arteries[96, 150, 151]