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oral melanotic macules of the tongue in a newborn Mucosal melanocytic macules
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While genetic and environmental determinants are well recognized, diet constitutes a modifiable factor capable of shaping immune regulation, inflammatory pathways, and gut microbiota compositioncentral mechanisms in autoimmune disease pathogenesis

When glycolysis and therefore the pyruvate supply for LDH is inhibited by 2-DG, oxamate strongly increased NADH/NAD+ ratios, likely by inhibition of AAT ( Fig

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