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1 Introduction Cancer persists as the second leading cause of global mortality, with epidemiological projections estimating 19.97 million new cases and 9.74 million deaths in 2024 ( Nutraceuticals have emerged as compelling candidates in translational oncology, leveraging their dual capacity to potentiate anticancer effects while mitigating treatment-related toxicity ( 2 O 2 )-mediated responses, including adenosine triphosphate (ATP) depletion, iron-regulated epigenetic reprogramming, anti-apoptotic protein B cell lymphoma 2 (Bcl-2) inhibition, Bax (Bcl-2 associated X protein, a well-known pro-apoptotic mediator) activation, mitochondrial hyperpolarization induction, the cleavage of poly (ADP-ribose) polymerase (PARP, a known apoptotic indicator) and caspases, mainly caspases 3 and 7 as well as targeting hypoxia-inducible factor-1 ( HIF- ) ( The therapeutic application of VC in oncology has been plagued by persistent controversies, particularly regarding dose-response relationships and administration route efficacy

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The gut microbiota is involved in various physiological responses, including nutrient absorption, energy regulation, glucose metabolism, and immune system regulation ( The Important Role of Gut Microbes in Covid-19 Patients with COVID-19 show signs of intestinal flora imbalance, which can cause intestinal damage and damage to the lung and vital organ systems in the event of a pathogenic SARS-CoV-2 infection

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Search strategy Two reviewers (LM, DF) systematically searched MEDLINE, Embase, and the Cochrane Library from inception to August 2023 using a comprehensive search strategy combining study design-, intervention-, and diagnosis-related search terms (see Table 1 for a complete list of antioxidants included in the review)

Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo