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In the case of HNE, the molecular mechanism appears to be species-specific and is dependent on the dose used (Iles and Liu, 2005

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in primary dermal fibroblasts

Although specialized FBS formulations remain valuable for certain niche applications, the overall trend favours GMP-compliant, XF, and ethically sourced media to improve reproducibility and translational relevance

Taken together, these studies underscore the therapeutic potential of iPSC-derived neural progenitors in PD models, yet the variability in reprogramming methods reported in the aforementioned studies, limited scalability, and unresolved concerns around long-term safety and functional integration highlight the need for more standardized and clinically validated approaches