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10.1002/mnfr.201300201 247 Tiekou LorinczovaH.FitzsimonsO.MursaleenL.RenshawD.BegumG.ZariwalaM

This collaborative approach will ensure a comprehensive understanding of the underlying mechanisms and expedite the translation of research findings into clinical applications

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AACR Annual Meeting 2024 84(10):17191732, 2024

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Dimeric (inactive) PKM2 creates a constriction through glycolysis at the terminal reaction resulting in the accumulation of glycolytic intermediates [6, 159], which are channeled into other pathways, such as the pentose phosphate pathway, which is an anabolic pathway which generates precursors for nucleotide and aromatic amino acid biosynthesis, all of which are necessary for the rapid proliferation typical of cancer cells