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doi: 10.1093/rheumatology/keg204 72 KabalaPAAngiolilliCYeremenkoNGrabiecAMGiovannoneBPotsDet al

This contrasts with mitochondrial bioenergetic changes seen in other models, such as induced pluripotent stem cell-derived neurons, and with findings in brain tissue showing elevated ATP, phosphocreatine level changes, and glucose metabolism in prefrontal and temporal regions, which correlate with negative symptoms and neuropsychological deficits ( Metabolic syndrome (MetS) profiles revealed an unusual pattern: despite lower BMI, waist circumference, LDL-c, and HDL-c than controls, patients with schizophrenia had higher triglyceride levels

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SIRP, signaling-regulatory protein alpha

Showed neuroprotective activity comparable to rasagiline

However, at higher doses or in the presence of oxidative stress and transition metals, curcumin can also interfere with COX-1 activity