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It interferes with the trafficking of melanogenic enzymes and inhibits tyrosinase activity and melanosome transfer in several ways
Greiner, R
In the enzyme acetylation reaction, lysine is deprotonated by the active site residues of KATs
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10.1177/1535370217746612 [DOI] [PMC free article] [PubMed] [Google Scholar] Wu, Y
This compartment-specific metabolism stems from the differential expression of acyl-CoA synthetase short-chain family isoforms: isoform 1 (mitochondrial) and isoform 2 (cytosolic/nuclear) (Fig
