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An absence of intrinsic factor is the most common cause of pernicious anemia

Deficiency is common, especially among vegetarians, vegans, and individuals with digestive issues, leading to fatigue, brain fog, and mood changes

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PKA catalyzes the polyphosphorylation of HSL on multiple sites, including a nonactivating site (Ser-563) as well as two additional sites (Ser-659 and Ser-660) that cause activation and subsequent translocation of this lipase from the cytosol to the lipid droplet (4, 51, 120)