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Subsequent in vitro and in vivo studies confirmed that PPAR activation led to the upregulation of key FAO genes, including CPT1B, LCAD, and MCAD, thereby shifting metabolic dependency toward FAO

Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice

10.1016/j.neuro.2023.02.003 NeuroToxicology 280 TanseyM

[DOI] [PubMed] [Google Scholar] Mizuno Y., Ohta S., Tanaka M., Takamiya S., Suzuki K., Sato T., Oya H., Ozawa T., Kagawa Y

This pathway is crucial for maintaining cartilage homeostasis, and its dysregulation can lead to increased catabolic activity, resulting in cartilage degradation and contributing to OA progression

Hepatocytes secrete bile acids, organic anions, organic cations, and lipids across their apical (canalicular) membranes At the apical membrane, the transport of compounds is generally unidirectional, from cell to canalicular lumen
