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To effectively distinguish the subtle pH differences between the TME and normal tissues and achieve TMEselective activation, the probes pKa should be close to 6.5, with a narrow response range that enables rapid switching between OFF and ON states

Additional anti-inflammatory effects exerted by itaconate include activation of the basic region leucine zipper (bZIP) transcription factor identified as nuclear factor erythroid erythroid 2 ( N EF2)- r elated f actor 2 (NRF2)