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It does not appear to cause serious AEs in test subjects and has been linked to only mild, temporary side effects such as headaches, fatigue, and localized swelling [1]

However, we know now that other forms of cell death, such as necroptosis, ferroptosis, and inflammasome mediated cell death/pyroptosis lead to oligodendrocyte death in the cuprizone model and occur at different time points after intoxication

However, the impact of LC has not been well-investigated, and the outcomes of these studies are controversial

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