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There have also been concerns raised in the scientific literature regarding cardiovascular safety

There is solid evidence that lactate levels correlate with elevated NH3 concentrations in the brain in patients with terminal liver disease

While its classified as a non-essential amino acidmeaning the body can synthesize itthis synthesis may be insufficient under certain conditions, including aging, metabolic stress, and chronic inflammation
Brevetti G, Perna S, Sabba C, et al

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EC metabolism has emerged as a novel and promising therapeutic target to block vascular dysregulation associated with various diseases
