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In response to an increase in the cytosolic Ca 2+ concentration, the Gardos channel opens, resulting in the efflux of K + with subsequent hyperpolarization driving Cl - exit (through Cl - channels)

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[DOI] [PubMed] [Google Scholar] 37.Benor S, Russell GH, Silver M, Israel EJ, Yuan Q, Winter HS

The gastrointestinal side effects of GLP-1 agonists stem from their mechanism of action
