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Specifically, GHK-Cu was found to be least possible to cause skin irritation, while CuCl 2 and Cu(OAc) 2 were found to induce the expression of various skin irritation biomarkers, i.e., IL-1, IL-8, FOSL1, and HSPA1A

The absorption challenge is inherent to the molecule itself, not just the delivery format

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And combining methods creates its own set of variables

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