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This oversimplifies the current state of research and can create unrealistic expectations

430 In an observational study of 321,501 patients with nonvalvular atrial fibrillation, apixaban, rivaroxaban, and dabigatran comparably decreased the risk of stroke and systemic thromboembolic events

Some research shows inconsistent results, and other findings raise concerns about over-supplementation, especially in cases of high-dose vitamin A, zinc, and folic acid, which can cause adverse effects

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For people with major depressive disorder, a more severe form of depression, one study found that vitamin B12 supplements, along with antidepressants, greatly improved symptoms