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This relationship is the main reason why the TSH level is used to guide treatment of hypothyroidism with LT4, as the large changes in TSH are far easier to measure than small changes in T4 or FT4 (within the traditional 95% normal range) in the routine setting [21, 26]

10.1186/s12964-023-01109-0 155

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During this process, the intermediate 16S,17S-epoxy-PD is hydrolyzed to generate PD1 and related PD conjugates, which contribute to tissue regeneration by regulating neutrophils, macrophages, eosinophils, and T cells [21]

Van der Vliet, A