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In addition, NADPH oxidase (NOX) family, which is able to decrease the available level of intracellular NADPH, was found to be upregulated in several RAS mutant tumors ( KRAS mutant Calu-1 non-small cell lung cancer cells ( Thioredoxin, a member of cellular antioxidant family (Nordberg and Arner, 2001), plays an important role in suppressing ferroptosis by maintaining and regulating the redox homeostasis

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Chemotherapy have been observed to reduce ascites volume, reaching up to an 80% reduction, with regression defined as an ascites volume below 500 ml

It enhanced cytokine expression and inhibited LPS-induced astrocyte activation [49]