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75 HCC cells with low H-ferritin expression are more sensitive to ras-selective lethal small molecule 3-induced ferroptosis

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Indeed, unlike other thiols, homocysteine incubation with endothelial cells induces an increased expression of the stress protein GRP78 and a decreased expression of glutathione peroxidase, a major intracellular antioxidant enzyme, through a mechanism that depends on an alteration of the intracellular redox potential (Kokame et al, 1996

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