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Commenters suggested that health outcome measures may need to include some form of adjustment for the relative amount and quality of resources available in different localities to care for different patient populations

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However, the lack of regulatory approval means comprehensive safety dataincluding potential effects on sexual functionhas not been systematically collected or evaluated

Rationale for choosing 50 g dose of vitamin B 12 Based on results from previous studies in this area, we expect the intake of vitamin B 12 among women in our study to be low, both due to a predominant plant-based diet and poor gut function that again may disturb vitamin B 12 absorption and increase dose requirements

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