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For instance, the N144D substitution is associated with iron buildup in tissues and liver cirrhosis

FASEB J (2019) 33:1182135

[DOI] [PubMed] [Google Scholar] 265.Roehlecke C., Schumann U., Ader M., Brunssen C., Bramke S., Morawietz H., et al

This causes molecular changes within the cells and ultimately leads to their death [23]

In vivo testing in xenograft mouse models confirmed that UCM 1037 suppressed DX3 tumor growth and demonstrated greater inhibitory activity compared to melatonin alone at the same dose (16 mg/kg) [87]

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