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The first is that S-glutathionylation may initially prevent O 2 production by Complex I but chronic/prolonged S-glutathionylation may have the opposite effect (e.g., increase O 2 production)

Wu D, Yang XO

Effect of Oral Administration of NAC on Relapse-Like Ethanol Drinking: Role of Glutamate mGlu2/3 Receptor and of the xCT-Cystine/Glutamate Exchanger Thirty-six female UChB rats, weighing 190210 g, were single housed in cages at the age of 60 days and maintained on a 12-h lightdark cycle (lights off at 7:00 PM)

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These strategies contribute to enhancing anti-tumor immunity ( Table 1 )