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86 The shift of glucose, sodium, and fluid transport to S3 segments, thick ascending limbs, and collecting ducts in the deep cortex and outer medulla may reduce the oxygen partial pressure in this region

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doi: 10.1007/s00726-008-0126-6

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Group 4 (DEX + SPAE 800): Received DEX (10 mg/kg, I/P) and SPAE orally at 800 mg/kg/day ( The 400 mg/kg and 800 mg/kg body weight/day doses for Spirulina platensis aqueous extract were selected based on previous studies demonstrating safety and hepatoprotective efficacy in rodent models ( Twenty-four hours after the final treatment following the 28-day study, delivery was conducted under ketamine/xylazine anaesthesia at dosages of 7.5 and 1.0 mg/kg by intraperitoneal infusion ( The liver specimens were preserved in a 10% formalin saline solution for histological analysis

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