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In this vein, macrophages, monocytes, neutrophils are responding by increasing levels of PAMPs (Pathogen-Associated Molecular patterns) and DAMPs (Danger-Associated Molecular Patterns) ( It is known that intruder's pathogens have a specific unique profile of PAMPs resulting in a specific immune response ( Without any doubt, there is a clear diversity in the patterns for pathogen recognition and host protection upon viral infections

Its function is tightly controlled by murine double minute (MDM) 2 and MDM4, which regulate p53 stability and activity through negative feedback mechanisms

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Neuropsychiatr Dis Treat 15:1429 Kanthan R, Shuaib A, Griebel R, El-Alazounni H, Miyashita H, Kalra J (1996) Evaluation of monoaminergic neurotransmitters in the acute focal ischemic human brain model by intracerebral in vivo microdialysis