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However, due to the low solubility and high metabolism of naringenin, its bioavailability before entering the systemic circulation is poor, which hinders its clinical efficacy (84)

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Preparation of knockout and stably expressing cell lines The CIP4 gene in PANC-1 cells was knocked out by using the CRISPR-Cas9 system

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The placebo drink consisted of the same ingredients (pineapple pulp, molasses, sodium chloride, flavor, steviol glycosides, sodium benzoate, potassium sorbate), except Pycnogenol

The F1 generation demonstrates 45% sperm count reduction and 38% testosterone decrease, while the F2 generation exhibits persistent sperm motility and morphological abnormalities attributable to heritable DNA methylation changes