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Unlike selective COX-2 inhibitors (coxibs), which block COX-2 activity while sparing COX-1, curcumin acts as a partial and condition-dependent inhibitor of both COX-1 and COX-2

AMPK, adenosine 5-monophosphate-activated protein kinase

Moreover, individuals of lower socioeconomic status who experience early-onset heart disease have a 32% higher long-term mortality rate than their higher-status counterparts (173)

Protective role of autophagy in palmitate-induced INS-1 beta-cell death
