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When you remove the exogenous signal abruptly, there's a lag period during which endogenous GHRH and ghrelin signaling must ramp back up to baseline

Crockford D, et al

2006 Mar;91(3):799-805

Within each cohort (with at least three female patients), six patients were randomized to NSI 189 phosphate and two patients were randomized to placebo, in this double blind, randomized, placebo controlled, multiple-dose study with three ascending cohorts ( N =24) (Figure 1)

Association versus causation A high B12 can be a marker of possible malignancy, rather than a cause of it

doi: 10.1172/JCI139681 172 HoskovaKBryantNKChenMENachtigallLBLippincottMBalasubramanianRet al