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In that context, the high oxidative burden in the tumor cells likely creates a dependency on the G6PD and TrxR1 functions as part of the adaptation mechanisms for tumor cell survival, given the roles of the two targets in cellular redox events [1, 2]

doi: 10.1038/srep08421

Hydrogen peroxide was also tested

10.1371/journal.pone.0001994 Summary Keywords cysteines, deglutathionylation, glutathione transferases, photosynthetic organisms, phylogeny Citation Lallement P-A, Brouwer B, Keech O, Hecker A and Rouhier N (2014) The still mysterious roles of cysteine-containing glutathione transferases in plants

In vitro studies showed that moderate cyclic loading had anabolic effect on disc cells, while static overloading showed catabolic effect 62

and Dixon S.J