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The transcription factor Nrf2 as a new therapeutic target in Parkinsons disease

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2011;13(5):R102

Studies have shown that evodiamine (which increases acetylation levels by approximately 34-fold at a concentration of 5 M) and paclitaxel (which induces peak acetylation within 30 min at 33 nM) both enhance NLRP3 inflammasome activation and subsequent pyroptosis by specifically promoting acetylation at lysine 40 (K40) of -tubulina process dependent on the acetyltransferase MEC-17thereby revealing their mechanisms of action in cancer therapy [283, 284]