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100 Sensitizing these mice with ovalbumin plus cholera toxin further alters the microbiota

Interestingly, ER stress has been associated with oxidative stress and the two often coexist in various pathological conditions but the underlying mechanism has remained elusive (13)

Ho et al

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Obesity cardiomyopathy is driven by metabolic and inflammatory stressors, including increased fatty acid uptake, lipid overaccumulation, impaired mitochondrial function, insulin resistance, endoplasmic reticulum (ER) stress, and chronic inflammation, resulting in left ventricular hypertrophy, diastolic dysfunction, cardiac fibrosis, and eventual heart failure