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J ClinNeurosci

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For example, in one aspect, there is provided a method of generating monocytes and/or macrophages having an increased inflammatory phenotype after contact with at least one agent, the method comprising contacting the monocytes and/or macrophages with an effective amount of the at least one agent, wherein the at least one agent is a) an agent that down-regulates the copy number, amount and/or activity of at least one target listed in table 1 and/or b) an agent that up-regulates the copy number, amount and/or activity of at least one target listed in table 2

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