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doi: 10.7554/eLife.83207, 4 AytonS.BartonD.BrewB.BrodtmannA.ClarnetteR.DesmondP.et al

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Imprecise estimation of GFR and overall kidney function coupled with inaccurate determination of drug dosing can lead to either suboptimal dosing or to an increased risk of anticancer therapy nephrotoxicity, especially in patients with CKD with an estimated increased risk of more than 1.8-fold 159 (Supplementary Table 3)