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It is not surprised that if we raised cytosolic GSTP level through GSTP plasmid transfection or treated mice with GSTP protein, the excessive inflammatory responses and mortality rate of CLP-induced sepsis were significantly reduced

4.2.4 Lactic acid bacteria metabolites Lactic acid bacteria produce various metabolites, including 1,3-diaminopropane (DAP), reuterin, and 5-methoxyindoleacetic acid (5-MIAA)

Functionally, this polymorphism modulates both the efficacy and safety of SSRI therapy: individuals carrying the S allele tend to exhibit blunted antidepressant response, slower onset of remission, and increased susceptibility to adverse effects, particularly when exposed to stressful environmental factors that intensify serotonergic dysregulation (Figure 2) ( FIGURE 2 In pharmacodynamic terms, 5-HTTLPR variation alters the neural homeostasis that underlies treatment response

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